As acidic chyme enters the duodenum from the stomach, what homeostatic response would the digestive system produce?

Intestinal gastrin would be released to stimulate gastric secretion and move more chyme into the duodenum.
The pancreas would decrease its secretion of alkaline pancreatic juice into the duodenum.
The enterogastric reflex would tighten the pyloric sphincter and decrease gastric secretion.
The duodenal brush border would secrete digestive enzymes that function in an acidic environment.
The enterogastric reflex would tighten the pyloric sphincter and decrease gastric secretion.  Homeostasis tends to respond to a detected change with “negative feedback”. The duodenum requires an alkaline environment, so the arrival of acidic chyme would result in a response that causes duodenal pH to rise. By closing the pyloric sphincter, the alkaline pancreatic juice and alkaline brush border secretions will have time to restore duodenal pH to the required level of about 7.4.

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